Proton Pump Inhibitor Long-term Prescription, Is It Safe?
نویسندگان
چکیده
منابع مشابه
Helicobacter pylori infection and long term proton pump inhibitor therapy.
S hould Helicobacter pylori infection be eradicated in patients requiring maintenance proton pump inhibitor therapy for gastro-oesophageal reflux disease? This question has stimulated heated debate and contention over the past few years. The issue first came to prominence in 1996 when Kuipers et al published their study purporting to demonstrate that omeprazole accelerated the development of co...
متن کاملAdvantages and Disadvantages of Long-term Proton Pump Inhibitor Use
Proton pump inhibitors (PPIs) potently inhibit gastric acid secretion and are widely used for treatment of acid-related diseases including gastroesophageal reflux disease and secondary prevention of aspirin/NSAID-induced ulcers. Although clinically important adverse effects of PPIs can occur, just as with other drugs, those are not frequently observed during or after administration. Thus, PPIs ...
متن کاملThe appropriateness of a proton pump inhibitor prescription.
Proton pump inhibitors (PPIs) are one of the most commonly prescribed groups of drug in Ireland, at great expense to the Irish healthcare executive. This study aims to evaluate the appropriateness of PPI prescriptions on admission and discharge in a tertiary referral hospital. All non-elective admissions in the Emergency Department in one week were included in the study. 102 patients in total w...
متن کاملWhen is proton pump inhibitor use appropriate?
Proton pump inhibitor (PPI) therapy is commonly used outside of Food and Drug Administration indication for a broad range of conditions such as extra-esophageal reflux and PPI-responsive esophageal eosinophilia. While this may be appropriate in some scenarios, it has also resulted in widespread inappropriate PPI use. At the same time, data suggesting adverse effects of long-term PPI therapy are...
متن کاملImpact of Long-Term Proton Pump Inhibitor Therapy on Gut Microbiota in F344 Rats: Pilot Study
Background/Aims To evaluate changes in gut microbiota composition following long-term proton pump inhibitor (PPI) treatment. Methods Twenty-four-week-old F344 rats were fed diets with (n=6) or without (n=5) lansoprazole for 50 weeks. Profiles of luminal microbiota in the terminal ileum were then analyzed. Pyrosequencing of the 16S rRNA gene was performed using an FLX genome sequencer (454 Lif...
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ژورنال
عنوان ژورنال: The Korean Journal of Helicobacter and Upper Gastrointestinal Research
سال: 2020
ISSN: 1738-3331,2671-826X
DOI: 10.7704/kjhugr.2020.0009